WebJan 27, 2024 · Background The coronavirus infection 2024 (COVID-19) is associated with microvascular endothelial injury. Here, we report that syndecan-1, a component of … Syndecan 1 is the most studied of all the syndecans in cancer research. Many studies have shown that syndecan 1 plays an important role in cancer progression, and also can be used as cancer biomarker. For example, syndecan 1 expression is higher in the bone marrow of the patients suffering from the … See more Syndecans are single transmembrane domain proteins that are thought to act as coreceptors, especially for G protein-coupled receptors. More specifically, these core proteins carry three to five heparan sulfate See more The syndecan protein family has four members. Syndecans 1 and 3 and syndecans 2 and 4, making up separate subfamilies, arose by gene duplication and divergent evolution from a … See more Functionality of syndecan is contributed by glycosaminoglycans which help in the interaction with different extracellular ligands. Depending upon the cellular localization of … See more Endometriosis Syndecan-4 is upregulated in endometriosis and inhibition of syndecan-4 in human endometriotic cells results in a reduction of invasive growth in vitro and changes in matrix metalloproteinase expression. See more Syndecans are expressed on the cell surface in a cell-specific manner. For example, in mouse cells and tissues, syndecan 1 is highly expressed in fibroblastic and … See more The syndecan proteins can contain the following protein domains, • A signal sequence; • An extracellular domain (ectodomain) of variable length whose sequence is not evolutionarily conserved in the various forms of syndecans. The … See more • MBInfo: Syndecans See more
Anti-Syndecan-1 antibody [B-A38] (ab34164) Abcam
WebSyndecan-2 has been implicated in the formation of specialized membrane domains and functions as a direct link between the extracellular environment and the organization of … WebMar 7, 2024 · Background Inflammatory breast cancer (IBC), a particularly aggressive form of breast cancer, is characterized by cancer stem cell (CSC) phenotype. Due to a lack of … fda crswnp
National Center for Biotechnology Information
WebSep 1, 2013 · Syndecan-4, a proteoglycan receptor, is a central mediator of cell adhesion, migration, proliferation, endocytosis and mechanotransduction. The broad effects of this molecule are exemplified … WebThe KY/8.2 mAb reacts with mouse syndecan-4, a cell-surface heparan sulfate proteoglycan. Although the ligand(s) for this molecule is unknown, syndecans are known to interact with … WebSyndecan-4 (Amphiglycan; Ryudocan core protein) is one of four members of the syndecan proteoglycan family. The syndecan proteins bind heparan sulfate and mediate the signaling of growth factors, such as fibroblast growth factor, that recognize and bind heparan chains. Unlike other members of this family, syndecan-4 is ubiquitously expressed ... froedtert career site