Flt3 antibody cst
WebFLT3 Mutational Analysis, PCR Indication. Detection of activating mutations in the receptor tyrosine kinase FLT3 that occur in 15% of acute myeloid leukemia. The mutations … WebOct 19, 2024 · Cell Signaling Technology. 3 Trask Lane. Danvers, MA 01923. [email protected]. www.cellsignal.com. 8776162355. headquarters: USA. Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools …
Flt3 antibody cst
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WebMar 2, 2007 · The rabbit hybridoma cell line C24D9, which produces monoclonal antibody CST #C24-D9 that binds Flt3 only when phosphorylated at tyrosine 969 (Tyr969, was deposited with the American Type Culture Collection, in accordance with the provisions of the Budapest Treaty on _____, 2007 and has been assigned ATCC Accession Number … WebMonoclonal Antibody for studying FLT3. Validated for Flow Cytometry (Live). Highly specific and rigorously validated in-house, FLT3 (BV10A4H2) Mouse Monoclonal Antibody (Alexa Fluor® 647 Conjugate) (CST …
WebApr 13, 2024 · Internal tandem duplication of FLT3 (FLT3-ITD) is one of the most common somatic mutations in acute myeloid leukemia (AML); it causes constitutive activation of FLT3 kinase and is associated with high relapse rates and poor survival.Small-molecule inhibition of FLT3 represents an attractive therapeutic strategy for this subtype of AML, although … WebMay 1, 2003 · Signaling via receptor tyrosine kinases (RTKs) is frequently dysregulated in disease. FLT3 (fms-related tyrosine kinase/Flk2/Stk-2) belongs to the type III split-kinase domain family of RTKs, and is primarily expressed on immature hematopoietic progenitors and also on some mature myeloid and lymphoid cells.1-3 FLT3 is activated following …
WebMar 10, 2024 · Background Most patients with acute myeloid leukemia (AML) remain uncurable and require novel therapeutic methods. Gain-of-function FMS-like tyrosine kinase 3 (FLT3) mutations are present in 30–40% of AML patients and serve as an attractive therapeutic target. In addition, FLT3 is aberrantly expressed on blasts in > 90% of … WebNov 8, 2024 · FLT3-ITD is the most predominant mutation in AML being expressed in about one-third of AML patients and is associated with a poor prognosis. Efforts to better …
WebMar 21, 2024 · GeneCards Summary for FLT3 Gene. FLT3 (Fms Related Receptor Tyrosine Kinase 3) is a Protein Coding gene. Diseases associated with FLT3 include Leukemia, Acute Myeloid and Acute Myeloblastic …
WebJul 15, 2016 · Abstract. FLT3 is a member of the class III receptor tyrosine kinase family that includes C-KIT, C-FMS and platelet derived growth factor receptor (PDGFR). FLT3 is primarily expressed in early myeloid and lymphoid progenitors and plays an important role in their proliferation and differentiation. In human leukemia, FLT3 is expressed on 70-90% … raymond\u0027s landing hubert ncWebJun 2, 2024 · Background: Mutations of the FMS-like tyrosine kinase 3 (FLT3) gene occur in approximately 30% of all acute myeloid leukemia (AML) cases, with the internal tandem … raymond\\u0027s landing coldwater miWebMar 26, 2024 · Simple Summary. Cancer immunotherapy is currently focused mainly on the enhancement of the effector function of T cells. However, dendritic cells (DCs) are needed to prime T cells, suggesting that DCs can be an attractive target for immunotherapy. Flt3L/Flt3 is an essential pathway for DC development and function, although its potential in ... raymond\u0027s landscaping concord nhWebMar 4, 2024 · A durable therapy that can target a wider population of AML patients is needed. Here, we developed an anti-FLT3-CD3 immunoglobulin G (IgG)-based … raymond\\u0027s kitchen irvine menuWebFMS-related tyrosine kinase 3 (FLT3, also called FLK2) is a member of the Type III receptor tyrosine kinase family, which includes c-Kit, PDGFR, … raymond\u0027s landing coldwater miWebSep 14, 2024 · As a tyrosine kinase, FLT3 represents an attractive therapeutic target, and the therapeutic effects of inhibiting FLT3 have been explored in leukemia, particularly in AML with FLT3 ITD 7,22,28,29 ... raymond\u0027s landing campgroundWebFLT3 is expressed on early hematopoietic progenitor cells and supports growth and differentiation within the hematopoietic system (1,2). FLT3 … raymond\u0027s landscaping