Cisplatin renal clearance
WebJan 3, 2024 · Formulas calculating creatinine clearance are inadequate for determining eligibility for Cisplatin-based chemotherapy in bladder cancer. J Clin Oncol 2006; … WebJan 11, 2024 · According to current clinical trial eligibility criteria, patients with muscle-invasive bladder cancer (MIBC) and baseline renal clearance of 40–60 ml/min can …
Cisplatin renal clearance
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WebCisplatin renal clearance, total clearance, and the percentage of the dose excreted unchanged in urine were significantly lower with the longer infusion. Total clearance was 345 +/- 97.0 mL/min/m2 after the two-hour infusion and 268 +/- 70.7 mL/min/m2 after the 24-hour infusion (P less than .0001). WebFeb 16, 2016 · We consider creatinine clearance a more accurate indicator than serum creatinine levels as it takes bodyweight into account. Nephrotoxicity during CCRT (Glomerular Filtration Rate [GFR] <50 mL/min) may require cisplatin dose reductions. This in turn, however, may lead to poorer treatment outcomes.
WebThe parent compound, cisplatin, is excreted in the urine and accounts for 13% to 17% of the dose excreted within one hour after administration of 50 mg/m 2 The mean renal clearance of... WebPretreatment with cisplatin has been reported to increase MTX toxicity, possibly by decreasing renal clearance (40). AKI prolongs extrarenal toxicity (myelosuppression …
WebThe mean renal clearance of cisplatin exceeds creatinine clearance and is 62 and 50 mL/min/m2 following administration of 100 mg/m2 as 2-hour or 6- to 7-hour infusions, … Web• Nephrotoxicity: cisplatin for injection can cause severe renal toxicity, including acute renal failure. Ensure adequate hydration. Consider dose reductions or alternative treatments in …
WebMar 2, 2024 · After several decades, cisplatin continues to be an essential drug for the treatment of several tumors, however, its potential nephrotoxicity is still a clinically relevant issue. Identification of predisposing factors for renal toxicity could be of value to warrant prophylactic measures. We analyzed data from 198 patients with various tumor types, …
WebFeb 16, 2024 · This drug can cause severe renal toxicity, including acute renal failure. Severe renal toxicities are dose-related and cumulative. Ensure adequate hydration and … cypress college calendar 2021cypress college cafeteriaWebApr 9, 2024 · Cisplatin has been the chemotherapy cornerstone for renal transitional cell carcinoma, but it's not for everyone. Learn about better options for patients with impaired … binary brotherWebSerum creatinine, blood urea nitrogen, electrolyte, and glomerular filtration rate (GFR) were measured at baseline and days 2 and 7. Moreover, GFR was calculated based on the 24-hour urine creatinine clearance rate to assess renal function at baseline and 48 hours after receiving cisplatin. cypress college bursar\u0027s officeWebApr 19, 2024 · The mean renal clearance of cisplatin exceeds creatinine clearance and was 62 mL/min per m² and 50 mL/min per m² following administration of 100 mg/m² as 2-hour or 6-to 7-hour infusions, respectively. Plasma concentrations of the parent compound, cisplatin, decrease monoexponentially with a half-life of about 20 to 30 minutes … binary brother meaning cobra kaiWebThe intraperitoneal injection of cisplatin increased kidney weight, serum cystatin-c, and serum creatinine, at the same time, decreased body weight, urinary volume, urine creatinine, creatinine clearance, and renal antioxidant activity, all of which were significant. binary buddy allocatorWebThe renal clearance of free (ultrafilterable) platinum also exceeds the glomerular filtration rate indicating that cisplatin or other platinum-containing molecules are … cypress college campus security